The Potentiometric Performances of the Cation Selective Electrodes based on Tetracycline and Chemically Modified Tetracycline

Kang, Sang-Hyuk; Rhee, In-Sook; Paeng, Ki-Jung

doi:2011.2.3.143

J. Electrochem. Sci. Technol > Volume 2(3); 2011 > Article

Article

Journal of Electrochemical Science and Technology 2011;2(3):143-145.
DOI: https://doi.org/10.5229/JECST.2011.2.3.143

The Potentiometric Performances of the Cation Selective Electrodes based on Tetracycline and Chemically Modified Tetracycline

Sang-Hyuk Kang, In-Sook Rhee, Ki-Jung Paeng

Department of Chemistry, Yonsei University;Department of Chemistry, Seoul Women's University;Department of Chemistry, Yonsei University;

Abstract

Metal-binding antibiotics are very attractive choices as cation selective ionophores. The ability of tetracycline (TC) antibiotics to bind to metal ions has obtained much attention. TCs exhibit the potentiometric performance changes for various cations dependant on several experiment conditions. In this report, we investigated the potentiometric performance changes of TC as the modification of TC's possible metal binding site. We found that the selectivity alter with the blocking main binding site of ionophores for cations. And, additionally it is possible to control the selectivity of sensors with chemical modification of ionophores.

Key Words: Tetracycline, Ion selective electrode, Potentiometric performance, Modified tetracycline